Antibiotic. Induces apoptosis, which is not prevented by the presence of Bcl-2. Inhibits mitochondrial electron transport specifically between cytochromes b and c1.
Product Details
| Alternative Name: | Antipiricullin, Virosin |
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| Source: | Isolated from Streptomyces sp. Mixture of antimycin A's. |
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| CAS: | 1397-94-0 |
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| MI: | 14: 714 (A1) & 715 (A3) |
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| RTECS: | CD0350000 |
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| Appearance: | White to faint yellow powder. |
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| Solubility: | Soluble in 100% ethanol (50mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Unexpected Role of Sterol Synthesis in RNA Stability and Translation in Leishmania: Z. N. Karamysheva, et al.; Biomedicines 19, 696 (2021), Abstract;
COQ11 deletion mitigates respiratory deficiency caused by mutations in the gene encoding the coenzyme Q chaperone protein Coq10: M.C. Bradley, et al.; J. Biol. Chem. 295, 6023 (2020), Abstract; Full Text
UBXD1 is a mitochondrial recruitment factor for p97/VCP and promotes mitophagy: A.C. Bento, et al.; Sci. Rep. 8, 12415 (2018), Abstract; Full Text
The Natural Product Mensacarcin Induces Mitochondrial Toxicity and Apoptosis in Melanoma Cells: B. Plitzko, et al.; J. Biol. Chem. 292, 21102 (2017), Abstract; Full Text
The effect of phosphate availability on chondrocyte metabolic function: K. Blank, et al.; (2016), (master's thesis), Application(s): Inhibitor of complex III in the electron transport chain, Full Text
An ROS generator, antimycin A, inhibits the growth of HeLa cells via apoptosis: W.H. Park, et al.; J. Cell. Biochem. 102, 98 (2007), Abstract;
Oligomycin and antimycin A prevent nitric oxide-induced apoptosis by blocking cytochrome C leakage: N. Dairaku, et al.; J. Lab. Clin. Med. 143, 143 (2004), Abstract;
Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3: S.P. Tzung, et al.; Nat. Cell Biol. 3, 183 (2001), Abstract;
Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3: S.P. Tzung, et al.; Nat. Cell. Biol. 3, 183 (2001), Abstract;
Biophysical characterization of recombinant human Bcl-2 and its interactions with an inhibitory ligand, antimycin A: K.M. Kim, et al.; Biochemistry 40, 4911 (2001), Abstract;
Synthetic peptides and non-peptidic molecules as probes of structure and function of Bcl-2 family proteins and modulators of apoptosis: D. Liu & Z. Huang; Apoptosis 6, 453 (2001), Abstract;
The effect of antimycin A on mouse liver inner mitochondrial membrane channel activity: M.L. Campo, et al.; J. Biol. Chem. 267, 8123 (1992), Abstract; Full Text
The isolation and properties of antimycin A: B. R. Dunshee, et al.; J. Am. Chem. Soc. 71, 2436 (1949),
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