InVivoSIM anti-human TROP-2 (Sacituzumab Biosimilar) clone: Sacituzumab (Catalog #SIM0051)
產品中文名稱:InVivoSIM 抗人TROP-2(Sacituzumab 生物仿制藥)抗體,克隆:Sacituzumab(目錄號 #SIM0051)
(產品示例圖)
Key features:
▲ Sacituzumab is a humanized IgG1κ against human trophoblastic cell surface antigen 2 (TROP-2).
▲ TROP-2 is a cell surface receptor, and its ligands include claudin-1, claudin-7, cyclin D1, and IGF-1.
▲ TROP2 is an upcoming tumor antigen that is expressed in glioblastoma, pancreatic carcinoma, and all breast cancer subtypes. TROP-2 is a cellular marker of trophoblastic stem cells.
▲ TROP2 transduces calcium signals and drives tumor proliferation, invasion, and metastasis.
▲ The tumor cell-specific expression of TROP-2 makes it an ideal target for cancer immunotherapy.
▲ Sacituzumab is used for making antibodydrug conjugates (ADC) and also to eradicate cancer cells.
Application: in vitro functional assays, in vivo functional assays, Antibody-drug conjugate synthesis, ELISA, Western blot, Flow cytometry
cytometry Research Area: Tumor Antigens, Cancer Biology
Related targets: EGFR, EPCAM (CD326), HER2/erbB2, PSMA, EphA2, CEACAM
主要特點:
▲ Sacituzumab 是一種針對人滋養細胞表 面抗原 2(TROP-2)的重組人源化 IgG1κ 抗體。
▲ TROP-2 是一種細胞表面受體,其配體 包括 claudin-1、claudin-7、cyclin D1 和 IGF-1。
▲ TROP-2 是新興的腫瘤抗原,表達于膠 質母細胞瘤、胰腺癌以及所有乳腺癌亞 型中。TROP-2 是滋養細胞干細胞的細 胞標志物。
▲ TROP-2 傳導鈣信號,并驅動腫瘤的增 殖、侵襲和轉移。
▲ TROP-2 在腫瘤細胞中的特異性表達使 其成為癌癥免疫療法的理想靶點。
▲ Sacituzumab 用于抗體藥物偶聯物 (ADC)的合成,同時也用于消除癌細 胞。
應用:體外功能實驗、體內功能實驗、抗體藥物偶 聯物合成、ELISA、Western blot、流式細胞術
研究領域:腫瘤抗原、癌癥生物學
相關靶點:EGFR、EPCAM(CD326)、HER2/erbB2、 PSMA、EphA2、CEACAM
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